Niclosamide Bolus 1250 mg
Niclosamide Bolus inhibits phosphorylation hauv mitochondria ntawm cestodes. Ob qho tib si hauv vitro thiab hauv vivo, scolex thiab proximal segments raug tua thaum kov cov tshuaj. Cov scolex uas xoob lawm yuav raug zom hauv txoj hnyuv; yog li ntawd, nws yuav tsis yooj yim sua kom paub qhov scolex hauv cov quav. Niclosamide Bolus yog taenicidal hauv kev ua haujlwm thiab tshem tawm tsis yog tsuas yog cov segments tab sis kuj scolex.
Niclosamide Bolus kev ua haujlwm tawm tsam cov kab zoo li yog vim muaj kev txwv ntawm mitochondrial oxidative phosphorylation; anaerobic ATP ntau lawm kuj raug cuam tshuam.
Qhov kev ua haujlwm cestocidal ntawm Niclosamide Bolus yog vim qhov kev txwv tsis pub cov kab tapeworm nqus cov piam thaj thiab qhov kev sib cais ntawm cov txheej txheem oxidative phosphorylation hauv mitochondria ntawm cestodes. Cov kua qaub lactic uas tau los ntawm kev thaiv ntawm Krebs cycle tua cov kab.
Cov cim qhia
Niclosamide Bolus yog qhia rau ob qho tib si tapeworm infestation ntawm Tsiaj Txhu, Nqaij Qaib, Dev thiab Miv thiab tseem nyob rau hauv immature paramphistomiasis (Amphistomiasis) ntawm Nyuj, Yaj thiab tshis.
Kab mob Tapeworms
Nyuj, Yaj, Tshis, thiab Mos Lwj: Moniezia Hom Thysanosoma (Fringed Tape worms)
Cov dev: Dipylidium Caninum, Taenia Pisiformis T. hydatigena thiab T. taeniaeformis.
NeesCov kab mob Anoplocephalid:
Nqaij qaib: Raillietina and Davainea
Kab mob Amphistomiasis: (Cov Paraphistomes Tsis Paub Tab)
Hauv nyuj thiab yaj, cov kab mob Rumen flukes (Paramphistomum hom) yog ib yam kab mob uas muaj ntau heev. Txawm hais tias cov kab mob flukes laus uas txuas rau ntawm phab ntsa rumen yuav tsis tseem ceeb npaum li cas los xij, cov uas tsis tau loj hlob tuaj yeem ua rau muaj kev puas tsuaj loj heev thiab tuag thaum lawv mus rau hauv phab ntsa duodenal.
Cov tsiaj uas muaj cov tsos mob ntawm kev tsis noj qab haus huv hnyav, haus dej ntau ntxiv, thiab raws plab nrog dej qab zib yuav tsum tau xav tias muaj tus kab mob amphistomiasis thiab kho tam sim ntawd nrog Niclosamide Bolus kom tiv thaiv kev tuag thiab kev poob ntawm cov khoom tsim tawm vim Niclosamide Bolus muab cov txiaj ntsig zoo heev rau cov kab mob flukes tsis tau loj hlob.
Kev sau ua ke
Txhua lub bolus uas tsis muaj txheej muaj:
Niclosamide IP 1.0 gm
Kev siv thiab koob tshuaj
Niclosamide Bolus hauv pub los yog zoo li ntawd.
Tiv thaiv cov kab mob Tapeworms
Nyuj, Yaj thiab Nees: 1 gm bolus rau 20 kg lub cev hnyav
Dev thiab Miv1 g ntawm cov tshuaj rau 10 kg ntawm qhov hnyav
Nqaij qaib: 1 gm bolus rau 5 tus noog laus
(Kwv yees li 175 mg rau ib kg ntawm qhov hnyav ntawm lub cev)
Tawm tsam Amphistomes
Nyuj thiab Yaj:Cov koob tshuaj ntau dua ntawm tus nqi ntawm 1.0 gm bolus / 10 kg lub cev hnyav.
Kev Nyab Xeeb:Niclosamide bolus muaj kev nyab xeeb ntau. Kev noj Niclosamide ntau dhau txog li 40 npaug rau cov yaj thiab nyuj tau pom tias tsis muaj tshuaj lom. Rau cov dev thiab miv, ob npaug ntawm cov tshuaj pom zoo tsis ua rau muaj kev phiv tsuas yog cov quav mos xwb. Niclosamide bolus siv tau zoo rau txhua theem ntawm kev cev xeeb tub thiab rau cov neeg tsis muaj zog yam tsis muaj kev phiv.
