Niclosamide Bolus 1250 mg
Niclosamide Bolus inhibits phosphorylation hauv mitochondria ntawm cestodes.Ob qho tib si hauv vitro thiab hauv vivo, scolex thiab cov ntu sib thooj raug tua ntawm kev sib cuag nrog cov tshuaj.Lub loosened scolex yuav zom tau hauv txoj hnyuv;Yog li ntawd, nws yuav tsis yooj yim sua kom paub cov scolex hauv cov quav.Niclosamide Bolus yog taenicidal hauv kev ua thiab tshem tawm tsis tsuas yog ntu tab sis kuj scolex.
Niclosamide Bolus kev ua haujlwm tawm tsam cov kab mob tshwm sim vim yog inhibition ntawm mitochondrial oxidative phosphorylation;anaerobic ATP ntau lawm kuj cuam tshuam.
Kev ua haujlwm cestocidal ntawm Niclosamide Bolus yog vim qhov inhibition ntawm absorbtion ntawm qabzib los ntawm tapeworm thiab uncoupling ntawm oxidative phosphorylation txheej txheem nyob rau hauv lub mitochondria ntawm cestodes.Cov lactic acid uas tsim los ntawm kev thaiv ntawm Krebs lub voj voog tua cov kab mob.
Cov lus qhia
Niclosamide Bolus yog qhia nyob rau hauv ob qho tib si kab mob kab mob ntawm cov tsiaj nyeg, nqaij qaib, dev thiab miv thiab tseem nyob rau hauv tsis paub tab paramphistomiasis (Amphistomiasis) ntawm nyuj, yaj thiab tshis.
Tapeworms
nyuj, yaj tshis thiab mos lwj: Moniezia Species Thysanosoma (Fringed Tape worms)
Cov dev: Dipylidium Caninum, Taenia Pisiformis T. hydatigena thiab T. taeniaeformis.
Nees: Kab mob Anoplocephalid
Nqaij qaib: Raillietina thiab Davainea
Amphistomiasis: (Tsis paub tab Paramphistomes)
Hauv nyuj thiab yaj, Rumen flukes (Paramphistomum hom) yog ntau heev.Txawm hais tias cov neeg laus flukes txuas rau ntawm phab ntsa rumen tuaj yeem yog qhov tseem ceeb me me, cov neeg tsis paub qab hau yog cov kab mob hnyav ua rau muaj kev puas tsuaj hnyav thiab kev tuag thaum tsiv hauv cov phab ntsa duodenal.
Tsiaj txhu uas qhia cov tsos mob ntawm qhov mob hnyav heev, kev noj dej ntau ntxiv, thiab dej fetid raws plab yuav tsum tau xav tias muaj amphistomiasis thiab tam sim ntawd kho nrog Niclosamide Bolus los tiv thaiv kev tuag thiab poob ntawm kev tsim tawm txij li Niclosamide Bolus muab kev ua tau zoo heev tiv thaiv cov kab mob tsis paub qab hau.
Kev sib xyaw
Txhua yam tsis muaj coated bolus muaj:
Niclosamide IP 1.0 g
Kev tswj hwm thiab ntau npaum li cas
Niclosamide Bolus nyob rau hauv pub los yog li ntawd.
Tawm tsam Tapeworms
nyuj, yaj thiab nees: 1 gm bolus rau 20 kg lub cev hnyav
Cov dev thiab miv: 1 gm bolus rau 10 kg lub cev hnyav
Nqaij qaib: 1 gm bolus rau 5 tus neeg laus noog
(kwv yees li 175 mg ib kg lub cev hnyav)
Tawm tsam Amphistomes
Nyuj & Yaj:Kev noj ntau dua ntawm tus nqi ntawm 1.0 gm bolus / 10 kg lub cev hnyav.
Kev nyab xeeb:Niclosamide bolus muaj qhov dav dav ntawm kev nyab xeeb.Kev noj ntau dhau ntawm Niclosamide mus txog 40 zaug hauv yaj thiab nyuj tau pom tias tsis muaj tshuaj lom.Hauv Cov dev thiab miv, ob zaug qhov pom zoo noj ua rau tsis muaj kev mob tshwm sim tsuas yog softness ntawm cov quav.Niclosamide bolus tuaj yeem siv nyab xeeb rau txhua theem ntawm cev xeeb tub thiab hauv cov kev mob tshwm sim yam tsis muaj kev phom sij.
